BTC 103 - Bioinformatics

 
Description
This course provides an introduction to some of the important fundamental skills sets in bioinformatics. In-depth descriptions of methods and algorithms provide background, while hand-on experience with software provides practical experience. Concepts and approaches to DNA and amino acid sequence alignment, homology, conserved domain identification, phylogenetic inference, array-based transcriptomics, quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) analysis and peptide identification searches are presented. Basic computer skills are required.

1. Identify molecular biology of genes, transcription and translation beyond basic principles of the central dogma.
2. Solve biological questions using biological databases containing sequences, clinical and structural information.
3. Retrieve information from biological databases.
4. Perform structure/function analysis of biological molecules using information obtained from database searches.
5. Perform DNA/protein sequence alignment and analysis as a result of database queries, specifically identifying homologs and conserved domains.
6. Identify differentially expressed genes from analysis of a microarray data set.
7. Interpret the output of a quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) experimental data.
8. Define peptide identification search algorithms given proteomics profile.

1. Central dogma of genetics
2. Database searching methods and sequence comparison
3. DNA /protein sequence alignment and analysis
4. Interpretation of microarray data sets
5. Interpretation of (qRT-PCR) experiments
6. Interpretation of proteomic profiles

• Critical Thinking and Problem Solving
• Technological Competence

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